Hormone Research in Paediatrics
Decreased Serum and Pineal Concentrations of Melatonin and N-Acetylserotonin in Aged Male HamstersPang S.F.a · Tang P.L.baDepartment of Physiology, University of Hong Kong, and bDepartment of Applied Science, Hong Kong Polytechnic, Hong Kong
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Article / Publication Details
Received: June 15, 1982
Accepted: November 10, 1982
Published online: November 26, 2008
Issue release date: 1983
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Serum and pineal concentrations of melatonin and N-acetylserotonin in 4-month-old (adult) and 15-month-old (senile) male hamsters were studied. The animals were adapted under 12:12 h light:dark cycle for a minimum of 1 month before they were decapitated at mid-light and mid-dark. Melatonin and N-acetylserotonin in the pineal and serum were extracted and quantified by radioimmunoassay. Diurnal variations (p < 0.05) were observed in the levels of pineal melatonin, pineal N-acetylserotonin and serum melatonin. There was, however, no day and night difference (p > 0.05) demonstrated in the levels of serum N-acetylserotonin in our studies. Moreover, the levels of pineal melatonin, pineal N-acetylserotonin and serum melatonin in the dark period and the level of serum melatonin in the light period of the adult hamster were higher (p < 0.05) than those of the senile animal, but the levels of serum N-acetylserotonin in the two age-groups studied demonstrated no significant differences (p > 0.05). Our studies indicate that in the hamster, the synthesis and secretion of pineal melatonin decrease with aging.
© 1983 S. Karger AG, Basel
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Article / Publication Details
Received: June 15, 1982
Accepted: November 10, 1982
Published online: November 26, 2008
Issue release date: 1983
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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