Hormone Research in Paediatrics

 

The Effect of Varying Doses of hCG on the in vivo Uptake by Rat Testis and Serum Testosterone Response

Veijola M. · Kellokumpu S. · Rajaniemi H.

Author affiliations

Department of Anatomy, University of Oulu, Oulu, Finland

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Horm Res 1984;19:191–199

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: April 28, 1983
Accepted: September 14, 1983
Published online: November 26, 2008
Issue release date: 1984

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

The in vivo uptake of human chorionic gonadotropin (hCG) in the rat testes and mode of the early testosterone response were studied after a single intravenous injection of varying doses of hCG. The uptake of hCG by the testes was parallel up to 6 h with all hormone doses, decreased thereafter to low level by 24 h with low hormone doses but continued to increase up to 24 h with the highest dose of hCG. The clearance rate of hCG from the blood was independent of the hormone dose used. Serum testosterone peaked gradullay earlier when the hCG dose increased, and the highest hCG dose caused a slightly biphasic response with maxima at 1 and 12 h, the former peak being more pronounced. These results suggest that the in vivo uptake of hCG in the testes is modulated by the hormone dose used and that the mode of early serum testosterone response to varying hCG doses is dose dependent.

© 1984 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: April 28, 1983
Accepted: September 14, 1983
Published online: November 26, 2008
Issue release date: 1984

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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