Hormone Research in Paediatrics
Prolactin
Involvement of Hypothalamic Dopamine in the Regulation of Prolactin SecretionReymond M.J. · Porter J.C.Division of Endocrinology, Department of Internal Medicine, University Hospital, Lausanne, Switzerland; Departments of Obstetrics and Gynecology, and Physiology, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Tex., USA
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Article / Publication Details
Published online: November 28, 2008
Issue release date: 1985
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
The neuroendocrine control of prolactin (PRL) secretion is known to be a multifactorial process, but dopamine (DA) secreted by the tuberoinfundibular dopaminergic (TIDA) neurons of the hypothalamus is believed to exert a predominant inhibitory control on the secretion of PRL. The secretory activity of the TIDA neurons, including the rate of biosynthesis of DA and the rate of release of the neurohormone into hypophysial portal blood, can be readily evaluated in the rat. In most conditions in which an altered secretion of PRL has been documented, an altered secretory activity of the TIDA neurons has been found. When an acute reduction in the secretion of DA is observed, an increased secretion of PRL is associated, with an inverse relationship between DA and PRL concentrations in hypophysial portal and systemic blood, respectively. However, the secretion of PRL can be regulated by PRL itself through stimulation of the secretory activity of the TIDA neurons, and consequently hyperprolactinemia can be observed concomitantly with a sustained high secretion of DA, as seen after treatment with estrogen. The short loop feedback of PRL secretion seems to be impaired in the aging rat, since a sustained reduced hypothalamic secretion of DA is observed in spite of long-term hyperprolactinemia.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Published online: November 28, 2008
Issue release date: 1985
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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