Nephron
Symposium on Proteinuria
The Role of the Kidney in the Metabolism of Plasma ProteinsStrober W. · Waldmann T.A.Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.
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Article / Publication Details
Received: April 02, 1974
Published online: November 28, 2008
Issue release date: 1974
Number of Print Pages: 32
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
The role of the kidney in the metabolism of plasma proteins can be defined by metabolic turnover techniques using representative radioiodinated, purified proteins. Low molecular weight (MW) proteins ( < 50,000 MW) readily transverse the glomerular filter and are largely taken up and catabolized by tubular cells; for this class of proteins the kidney is a primary organ of catabolism. Intermediate and high M W proteins ( > 60,000 M W) are generally retained by the glomerular filter and, therefore, do not normally have a significant exposure to tubular catabolic sites; for this class of proteins the kidney is not normally a primary organ of catabolism. Intermediate and even high M W proteins do pass through an abnormal glomerular filter, and are thereby lost to the body as intact proteins or are taken up and catabolized within tubular cells. In tubular diseases low MW proteins enter the tubular lumen in normal fashion, but are not taken up and catabolized within tubular cells. Thus, their loss pathway changes reciprocably from one of endogenous catabolism to excretion; this is the origin of tubular proteinuria. In nephron-loss disease, both excretion and endogenous catabolism of low MW proteins are diminished. Thus, these proteins accumulate in the blood.
© 1974 S. Karger AG, Basel
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Article / Publication Details
Received: April 02, 1974
Published online: November 28, 2008
Issue release date: 1974
Number of Print Pages: 32
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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