Hormone Research in Paediatrics

 

Imprinting of Male Sex Tissues by Neonatal Endogenous Androgens in Mice

Molecular Alterations following Exposure to Cyproterone Acetate

Jean-Faucher C. · Berger M. · Gallon C. · de Turckheim M. · Veyssière G. · Jean C.

Author affiliations

Physiologie Comparée et Endocrinologie, CNRS LA 360, Université Clermont II, Complexe Scientifique des Cézeaux, Aubière, France

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Horm Res 1986;24:38–45

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: October 10, 1985
Accepted: December 19, 1985
Published online: November 28, 2008
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

This study was conducted to evaluate the growth and biochemical responsiveness of the epididymis, vas deferens and seminal vesicles of adult mice exposed to cyproterone acetate during the first 10 days of life. Results indicate that the weight and protein content of sex accessory organs were significantly depressed, testosterone and dihydrotestosterone concentrations were unaffected or increased, the number of cytosolic androgen-binding sites was slightly or significantly reduced. The efficiency of exogenous testosterone in promoting growth and protein synthesis in target organs of castrated adult males was significantly lowered by neonatal cyproterone acetate treatment. It is concluded that a deficient androgenic stimulation during neonatal life induces a limited response of sex target organs to endogenous or exogenous androgens in adulthood.

© 1986 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: October 10, 1985
Accepted: December 19, 1985
Published online: November 28, 2008
Issue release date: 1986

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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