Hormone Research in Paediatrics
Cholinergic Mediation in Dermorphin-Induced Growth Hormone Secretion in Mandegli Uberti E.C.a · Trasforini G.a · Salvadori S.b · Margutti A.a · Bianconi M.a · Teodori V.a · Tomatis R.b · Pansini R.aInstitutes of aClinical Medicine, and bPharmaceutical Chemistry, University of Ferrara, Italy
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Article / Publication Details
Received: November 18, 1985
Accepted: February 06, 1986
Published online: November 28, 2008
Issue release date: 1986
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
The effects of pirenzepine (P), a cholinergic muscarinic antagonist, on growth hormone (GH) and prolactin (PRL) response to dermorphin (D) were studied in a group of 7 healthy men. D produced clear elevations in GH and PRL levels. P completely blocked the GH-releasing activity of D, whereas it did not alter the PRL-releasing activity. These results indicate that GH-releasing action of D is mediated via the central cholinergic nervous system in man.
© 1986 S. Karger AG, Basel
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Article / Publication Details
Received: November 18, 1985
Accepted: February 06, 1986
Published online: November 28, 2008
Issue release date: 1986
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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