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Round Table on Graves’ Ophthalmopathy

Plasma Exchange Therapy for Severe Graves’ Ophthalmopathy

Glinoer D. · Schrooyen M.

Author affiliations

Departments of Internal Medicine and Ophthalmology, Hôpital Saint-Pierre, Université libre de Bruxelles, Belgium

Related Articles for ""

Horm Res 1987;26:184–189

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Article / Publication Details

First-Page Preview
Abstract of Round Table on Graves’ Ophthalmopathy

Published online: November 28, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

The authors report on the treatment of 11 Graves’ disease patients with severe ophthalmopathy by the use of intensive plasma exchange followed by immunosuppression. Results were evaluated by comparing the opthalmopathy index and the orbital CT scan performed before and after plasmapheresis. Favorable results were obtained in 91 % of the patients. The best positive effects of plasmapheresis were observed for soft tissue involvement, proptosis, tonometry, and visual acuity. Furthermore, a significant reduction in the size and density of enlarged extraocular muscles was also found. Six months after withdrawal of immunosupression, 4 patients presented a moderate recurrence of ophthalmopathy and were treated successfully by a second course of plasmapheresis, followed by short immunosuppression. In conclusion, the use of intensive plasma exchange associated with immunosuppression is an effective approach to the treatment of severe Graves’ ophthalmopathy. It yields rapid and dramatic improvements that are maintained in most patients after withdrawal of immunosuppression. Recurrences are still responsive to the beneficial effects of this combined treatment.

© 1987 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Round Table on Graves’ Ophthalmopathy

Published online: November 28, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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