Hormone Research in Paediatrics
Original Paper
Growth Hormone Secretion during Pregnancy: Altered Effects of Growth Hormone Releasing Factor and Insulin-Like Growth Factor-I in vitroSheppard M.S.a · Bala R.M.bDepartments of aPhysiology and bMedicine, University of Saskatchewan, Saskatoon, Sask., Canada
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Article / Publication Details
Received: January 27, 1987
Accepted: May 11, 1987
Published online: November 28, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Growth hormone (GH) secretion is controlled by growth hormone releasing factor (GRF) but changes in the circulating level of this hormone are difficult to measure. Insulin-like growth factor (IGF-I) is a GH-dependent growth factor which significantly but slightly inhibits stimulated GH release in vitro. We have tested the effects of GRF and IGF-I on GH release in pregnancy, a state in which serum concentrations of GH are elevated and levels of IGF-I are lowered. We have found, in a system of acutely dispersed adenohypophysial cells prepared from pregnant (day 21–23) or control cycling female rats, that adenohypophysial cells from pregnant rats have an increased GH release with GRF. In contrast, IGF-I inhibition is similar but slightly smaller. These altered responses may result in elevated serum GH levels during pregnancy.
© 1987 S. Karger AG, Basel
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Article / Publication Details
Received: January 27, 1987
Accepted: May 11, 1987
Published online: November 28, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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