Hormone Research in Paediatrics
Original Paper
Response of Serine Antiproteases to Growth Hormone Therapy in Growth Hormone Deficient ChildrenSchwarzenberg S.J. · Sharp H.L. · Freier E.F. · Seelig S.Departments of Pediatrics and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minn., USA
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Article / Publication Details
Received: August 17, 1988
Accepted: February 23, 1989
Published online: December 02, 2008
Issue release date: 1989
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Growth hormone regulates the hepatic mRNA levels of α1-antitrypsin and two contrapsin-like mRNAs in the rat. To determine whether growth hormone regulates similar serine protease inhibitors in humans, we measured serum α1-antitrypsin, α1-antichymotrypsin, and antithrombin III by radioimmunodiffusion in 16 growth hormone deficient children before and after growth hormone therapy. Of the 19 determinations made, 17/19 showed an increase in α1-antirypsin after administration of growth hormone, 198.6 ± 39.1 mg/dl before growth hormone and 239.4 ± 44 mg/dl after growth hormone (p = 0.005). Specificity of the response for α1-antitrypsin was indicated by the fact that neither α1-antichymotrypsin or antithrombin III values changed after growth hormone (p = 0.6 and 0.5, respectively). These data are compatible with the hypothesis that growth hormone regulates serine protease inhibitors in humans and suggests that investigation of other members of the serpin gene family might prove fruitful in defining additional growth hormone target genes.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Received: August 17, 1988
Accepted: February 23, 1989
Published online: December 02, 2008
Issue release date: 1989
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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