Nephron
Original Paper
Studies on the Natural History of the Norepinephrine Model of Acute Renal Failure in the DogBaehler R.W. · Williams R.H. · Work J. · Gottschall J. · Chuang V.Medical Service, Veterans Administration Medical Center, and Departments of Pathology and Radiology, University of Kentucky Medical Center, Lexington, Ky.
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Article / Publication Details
Accepted: April 17, 1980
Published online: December 02, 2008
Issue release date: 1980
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Studies on the natural history of the norepinephrine (NE) model of acute renal failure (ARF) in the dog. Group I (n = 6) was infused with NE into the renal artery (0.75 µg/kg/min × 80 min) and glomerular filtration rate (GFR) determined sequentially. 21 days post-NE infusion (I) the GFR of the I kidneys (20 ± (SE) 5 ml/min) remained less (p < 0.001) than the pre-I control value (44 ± 2.9). Group II (n = 7) was treated in an identical fashion except that a contralateral nephrectomy (CN) was done on day 7 and the animals were prepared for micropuncture on day 16. In the animals with residual nephron function at CN, the GFR increased (p < 0.02) from 26 ± 6.4 ml/min on day 7 to 38 ± 6.6 ml/min on day 14. Considerable interanimal heterogeneity of single nephron GFR (SNGFR) was demonstrated and morphologic studies revealed a very patchy lesion. Therefore, the model is reversible, heterogeneity of SNGFR is present, and the residual functioning nephrons have the capacity to undergo an increase in GFR after CN.
© 1980 S. Karger AG, Basel
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Article / Publication Details
Accepted: April 17, 1980
Published online: December 02, 2008
Issue release date: 1980
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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