Nephron
Original Paper
Circulating Immune Complexes after Cadaver Kidney TransplantationKaden J. · Falck P. · Groth J. · Mebel M.Städtisches Krankenhaus im Friedrichshain, Department of Urology, Chair of Urology and Division of Clinical Immunology of the Humboldt University, Berlin, GDR
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Article / Publication Details
Accepted: September 16, 1980
Published online: December 02, 2008
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the C1q solid-phase radioimmune assay. Increased C1q-binding activity (C1q-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chronic glomerulonephritis (GN). A significant decrease of C1q-BA immediately after transplantation could not be found. 6 weeks after transplantation only 2 patients of the PN group showed increased C1q-BA. Serial studies in 17 patients with rejection crises did not show any correlation between the level of serum C1q-BA and the occurrence of rejections. Furthermore, no correlation could be found between the occurrence of complement-dependent lymphocytotoxic antibodies measured by the 51Cr release technique and the level of serum C1q-BA. In contrast, our results show that the probability of graftectomy or graft failure is significantly higher, at least in the early phase after transplantation, when the serum C1q-BA is lowered for several weeks.
© 1981 S. Karger AG, Basel
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Article / Publication Details
Accepted: September 16, 1980
Published online: December 02, 2008
Issue release date: 1981
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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