Hormone Research in Paediatrics
Original Paper
Effects of Estrogen, Pituitary Gonadotropins and Prolactin on Immunohistochemical Localization of Inhibin Subunits in the Ovary of Hypophysectomized Female RatsKobayashi M. · Yamoto M. · Minami S. · Nakano R.Department of Obstetrics and Gynecology, Wakayama Medical College, Wakayama, Japan
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Article / Publication Details
Received: October 28, 1991
Accepted: April 10, 1992
Published online: December 03, 2008
Issue release date: 1992
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
Effects of estrogen, pituitary gonadotropins and prolactin on immunohistochemical localization of α- and βA-subunits in the ovaries of hypophysectomized female rats were investigated. Hypophysectomy resulted in disappearance of immunoreactive inhibin subunits in the ovary. Administration of DES, FSH and LH to hypophysectomized rats provoked growth of follicles, and resulted in positive immunostaining for inhibin subunits in the granulosa cells. In contrast to follicle-stimulating hormone (FSH) and luteinizing hormone (LH), prolactin administration failed to demonstrate positive staining for inhibin subunits in the ovary. The present in vivo results suggest that several hormones which are known to stimulate granulosa cell growth and maturation, such as estrogen, FSH and LH, enhance inhibin subunit production by the overy. The morphologic aspect of inhibin subunit production by the ovary in response to several hormones has been demonstrated in the present study.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: October 28, 1991
Accepted: April 10, 1992
Published online: December 03, 2008
Issue release date: 1992
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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