Nephron
Original Paper
Effects of Chronic Sodium Depletion on Renal Tubular Sodium and Water Reabsorption in ManDiScala V.A.a · Stein R.M.baRenal Service, Department of Medicine, US Public Health Service Hospital, Staten Island, N.Y., USA; aNephrology Division, Department of Medicine, Nassau Hospital, Mineola, N.Y., USA bDivision of Renal Diseases, Department of Medicine Mt. Sinai School of Medicine, New York, N.Y., USA
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Article / Publication Details
Accepted: September 22, 1981
Published online: December 03, 2008
Issue release date: 1982
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day Na diet and administering furosemide (40 mg) daily for 3 days. Balance studies revealed that the subjects were in Na balance under control conditions, and that after sodium depletion had been established they were in a sodium-retaining state. Subjects were studied under both conditions, after H2O hydration and during a subsequent hypotonic mannitol infusion. After H2O hydration the minimal urinary osmolality averaged 61 and 67 mosm/kg in the sodium depletion and control states, respectively. Sodium depletion was associated with a significant reduction in C inulin, sodium clearance (CNa), urine flow (V), fractional urine flow (V/GFR), free water (CH2O), and fractional free water clearance (CH2O/GFR). During hypotonic mannitol infusion indices of absolute and fractional delivery of Na from the proximal tubule (CH2O + CNa; CH2O/GFR + CNa/GFR) were consistently reduced after sodium depletion and rose more slowly as absolute and fractional fluid delivery to the loop of Henle (V; V/GFR) were increased. Indices of absolute and fractional sodium chloride transport in the distal tubule (CH2O; CH2O/GFR) rose at a significantly sharper rate after sodium depletion as absolute and fractional distal sodium chloride supply (CH2O + CNa; CH2O/GFR + CNa/GFR) were increased. These data are consistent with the view that modest sodium depletion in man provokes an increase in fractional sodium chloride reabsorption in both the proximal and distal tubules.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Accepted: September 22, 1981
Published online: December 03, 2008
Issue release date: 1982
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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