Hormone Research in Paediatrics
Original Paper
Effect of Small Doses of Iodine on Thyroid Function during Caloric Restriction in Normal SubjectsReinhardt W. · Holtermann D. · Benker G. · Olbricht T. · Jaspers Ch. · Reinwein D.Department of Clinical Endocrinology, Medical Clinic, University of Essen, FRG
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Article / Publication Details
Received: December 07, 1992
Accepted: April 23, 1993
Published online: December 03, 2008
Issue release date: 1993
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
It is well recognized that starvation and malnutrition are associated with a low-T3 syndrome in man. A similar condition has been observed after intake of a low carbohydrate hypocaloric diet. However, little is known about the influence of iodine on these conditions. Therefore, we evaluated the effect of iodine supplementation on thyroid function before and after a short-term intake of a low carbohydrate diet in normal subjects residing in an iodine-deficient area. The study was performed in 16 young euthyroid, nonobese volunteers (11 males, 5 females). The subjects were placed on a low carbohydrate (800 kcal) diet for 4 days. Eight subjects received 500 µg iodine (oral) daily beginning 4 weeks before diet. The control group (n = 8) received no iodine. After iodine supplementation, iodine excretion increased from 52 to 405 µg iodine/g of creatinine. Total T4 showed a slight but significant increase (104.2 nmol/lvs. 115.8 µg/dl;p < 0.001);fT4 was unchanged. The intake of the hypocaloric low carbohydrate diet resulted in a striking decrease in both total and free T3 and an increase of rT3 irrespective of iodine supplementation. T4 and fT4 were not affected in either group. During diet, iodine administration resulted in a decrease of basal TSH from 2.3 to 1.2 mU/1 (p < 0.05), ΔTSH from 10.3 to 4.5 mU/1 (p < 0.01) and ΔT3 (T3 180 min after TRH) from 0.7 to 0.3 nmol/l (p < 0.01). In contrast, no significant changes of basal TSH and T3 response after TRH were seen during diet in the control group. In conclusion, changes of T3, rT3 and rT3 during caloric restriction occurred irrespective of iodine supplementation. However, significant alterations in basal TSH and T3 response after TRH could only be demonstrated in subjects receiving iodine supplementation.
© 1993 S. Karger AG, Basel
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Article / Publication Details
Received: December 07, 1992
Accepted: April 23, 1993
Published online: December 03, 2008
Issue release date: 1993
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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