Nephron

Original Paper

Effects of Different Forms of Dialytic Treatment on Serum Antibacterial Activity in Patients with Chronic Renal Failure

Minelli Bertazzoni E.a · Panzetta G.b

Author affiliations

aInstitute of Pharmacology and bDivision of Nephrology, University Hospital, Verona, Italy

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Nephron 1984;36:224–229

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: June 06, 1983
Published online: December 03, 2008
Issue release date: 1984

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

The antibacterial activity of fresh and heat-inactivated normal serum was compared with that of sera from patients with renal failure: 16 on diet, 9 on regular hemodialysis (HD) and 9 on continuous ambulatory peritoneal dialysis (CAPD). The antibacterial activity was determined on Proteus rettgeri (Sanelli) by a turbidimetric method. The inhibitory activity of fresh serum was only slightly descreased in nondialyzed uremic patients, whereas it was significantly impaired in CAPD and HD patients. Heat-inactivated normal serum (56°C, 30 min) lost its antibacterial activity. Only CAPD patients’ sera behaved as the normal ones. In fact, a consistent residual antibacterial activity was found in heat-inactivated sera of nondialyzed and hemodialyzed patients. The results are in keeping with the view that uremic patients have reduced host-defence reactions. Dialysis treatment appears to further depress the antibacterial capacity of uremic patient’s sera. The residual antibacterial activity of heat-inactivated sera is due to substances, not present in normal controls, which act with a mechanism independent of the complement system. CAPD seems more effective than hemodialysis in removing these substances.

© 1984 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: June 06, 1983
Published online: December 03, 2008
Issue release date: 1984

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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