Nephron

Original Paper

Insulin Release from Column-Perifused Isolated Islets of Uremic Rats

Nakamura Y. · Yoshida T. · Kajiyama S. · Kitagawa Y. · Kanatsuna T. · Kondo M.

Author affiliations

First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Nephron 1985;40:467–469

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: November 05, 1984
Published online: December 04, 2008
Issue release date: 1985

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

In order to examine the insulin secretion in chronic renal failure, isolated pancreatic islets either from uremic rats or from control rats were mixed into a short column of Bio-Gel P-2 polyacrylamide beads and perifused. Uremic rats had higher concentrations of blood urea nitrogen, serum creatinine, and immunoreactive insulin and lower concentration of plasma 1,25-(OH)2D3 than control rats. Although the basal insulin release in the presence of 5.0 mMglucose showed no difference between uremic and control rats, the initial insulin release in the presence of 16.2 mMglucose was significantly lower (p < 0.05) in uremic than in controls rats. The insulin content in islets was not different between both groups. These findings suggest that there might be impairment of the initial insulin secretion without changes of insulin content in pancreatic islets in uremia.

© 1985 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: November 05, 1984
Published online: December 04, 2008
Issue release date: 1985

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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