Nephron
Short Communication
Plasmapheresis in a Patient with Rapidly Progressive Idiopathic IgA Nephropathy: Removal of IgA-Containing Circulating Immune Complexes and Clinical RecoveryCoppo R.a · Basolo B.a · Giachino O.b · Roccatello D.c · Lajolo D.b · Mazzucco G.c · Amore A.a · Piccoli G.aaDepartment of Medical Nephrology, University of Turin, and Department of Nephrology and Dialysis, S. Giovanni Hospital, Turin; bAVIS Blood Transfusion Center, Turin; cMorbid Anatomy Institute, University of Turin, Italy
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Article / Publication Details
Accepted: November 05, 1984
Published online: December 04, 2008
Issue release date: 1985
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Primary IgA nephropathy is generally considered a benign disease, but progression to renal failure is not uncommon and a rapidly progressive course is observed in some cases, especially when extensive epithelial crescents are present. Circulating IgA-containing immune complexes (IgAIC) seem to play the most important pathogenetical role, hence the authors adopted plasmapheretic treatment in association with immunosuppressive drugs for 1 patient affected by primary IgA nephritis, with florid crescents and progressive renal failure. IgAIC decreased significantly after each plasma exchange and finally returned to normal values; over the same period urinary protein loss and heavy microscopic hematuria gradually disappeared and renal function was completely recovered.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Accepted: November 05, 1984
Published online: December 04, 2008
Issue release date: 1985
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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