Nephron
Original Paper
Human α1-Microglobulin and Its Relationship to Renal FunctionKusano E.a · Suzuki M.a · Asano Y.a · Itoh Y.b · Takagi K.b · Kawai T.baDepartment of Cardiology and Kidney Center and bDepartment of Clinical Pathology, Jichi Medical School, Tochigi, Japan
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Accepted: March 15, 1985
Published online: December 04, 2008
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
To evaluate the clinical usefulness in terms of estimation for glomerular filtration rate (GFR), we determined the levels of α1-microglobulin (α1m) in the serum and urine of patients with various renal diseases and compared with those of β2-microglobulin (β2m) and creatinine. Serum and urinary α1m levels were measured by using single-radial immunodiffusion method. 24-hour creatinine clearance (Ccr) was used as a indicator of GFR. There was a significant positive correlation between serum α1m and creatinine levels (r = 0.75, p < 0.001). Serum α1m, β2m and creatinine inversely correlated and logarithmically correlated to Ccr as shown in the following equations: log α1m = 2.30 – 0.42 × log Ccr (r = – 0.74); log β2m = 2.06 – 0.91 × log Ccr (r = – 0.92); log creatinine = 1.57 – 0.78 × log Ccr (r = – 0.94). Both correlation coefficient and regression coefficient for α, m were rather poor compared to those for β2m and creatinine. However, α1m levels started to increase over normal range when Ccr fell below 80 liters/day, while β2m and creatinine remained within normal ranges.The daily urinary excretion of α1m was increased in the patients whose Ccr was within normal limits compared to that of healthy control subjects (15.2 ± 3.2 mg/day, n = 19, vs. 5.7 ± 0.7, n = 7, p < 0.001). Fractional clearance of α1m increased proportionally to the decrease of Ccr. These data suggest that combined measurements of α1m in the serum and urine seem to be useful to estimate GFR, especially to detect the mild reduction of CFR.
© 1985 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Accepted: March 15, 1985
Published online: December 04, 2008
Issue release date: 1985
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission