Nephron

Original Paper

Circadian Rhythm of Urinary β2Microglobulin Excretion in Patients with a Nephrotic Syndrome

Koopman M.G. · Krediet R.T. · Zuyderhoudt F.M.J. · de Moor E.A.M. · Arisz L.

Author affiliations

Renal Unit, Department of Medicine, and Laboratory of Medical Physics, Academic Medical Centre, Amsterdam, The Netherlands

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Nephron 1987;45:140–146

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: May 14, 1986
Published online: December 05, 2008
Issue release date: 1987

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

The changes in urinary β2microglobulin excretion during the day were studied in 20 patients with a nephrotic syndrome under standardized conditions and compared with the known circadian variations in urinary albumin excretion in the same patients. Fifteen of the 20 patients (75%) had a circadian rhythm for β2microglobulin in the urine. Phase as well as relative amplitude of the β2microglobulin circadian rhythm varied between patients. In addition, its presence, normality, amplitude and phase were largely different from the albumin rhythm. Observations made in 10 healthy individuals suggest that day-night variability in the excretion of β2microglobulin and albumin in the urine is also present in the absence of clinically important proteinuria. Circadian variations in urinary β2microglobulin excretion are found in a majority of the patients with nephrotic syndrome and as they differ in several respects from the day-night fluctuation in urinary albumin excretion the mechanism is probably different.

© 1987 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: May 14, 1986
Published online: December 05, 2008
Issue release date: 1987

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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