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Original Paper

Short-Term Changes in Urinary Growth Hormone Excretion and Lower Leg Length in Healthy Children

Ahmed S.F.a · Barnes S.I.b · Wallace W.H.B.a · Kelnar C.J.H.a

Author affiliations

aDepartment of Child Life and Health, University of Edinburgh, and bDepartment of Immunoassay, Royal Infirmary of Edinburgh, UK

Related Articles for ""

Horm Res 1997;48:72–75

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 1996
Accepted: February 07, 1997
Published online: December 10, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

To investigate any association between changes in lower leg length (LLL) and urinary growth hormone (uGH) excretion, 4 prepubertal children supplied daily 12-hour overnight urine samples and had daily knemometry performed for 4 weeks. The mean daily and weekly LLL velocity (LLLV) of the group was 0.08 mm/day (95% CI 0.01-0.18) and 0.52 mm/week (range 0.38-0.78), respectively. The mean uGH excretion was 8.9 ng/l (CI 3.7-13.3), and the mean intrasubject coefficient of variation of uGH was 55% (range 32-93). The tallest subject who also had the highest LLLV excreted the least amount of uGH (mean 3.7 ng/l, CI 2.9-4.5). No temporal relationship was evident between daily uGH excretion and LLL changes. There was no evidence of any association between amount of uGH excreted and LLLV. There remains some doubt on the usefulness of uGH measurement as the sole predictor of normal GH production.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 09, 1996
Accepted: February 07, 1997
Published online: December 10, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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