Nephron
Original Paper
Hemolytic-Uremic Syndrome with Anticardiolipin Antibodies Revealing Paraneoplastic Systemic SclerodermaMeyrier A.a · Becquemont L.a · Weill B.b · Callard P.c · Rainfray M.aaService de Néphrologie, Hôpital Avicenne, Bobigny; bLaboratoire d’lmmunologie Clinique, Hôpital Cochin, Paris; cLaboratoire d’Anatomopathologie, Hôpital Jean Verdier, Bondy, France
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Article / Publication Details
Accepted: January 18, 1991
Published online: December 11, 2008
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Lupus anticoagulant was present in this case of paraneoplastic scleroderma revealed by hemolytic-uremic syndrome, suggesting that the autoantibody played a significant role in the sequence of events leading to anuria. Reviewing the literature we found several observations of paraneoplastic scleroderma, and in other series cases of scleroderma-linked (and in rare instances cancer-linked) antiphospholipid autoantibodies. Search for antiphospholipid antibodies should be considered in patients with systemic scleroderma as well as in patients with metastatic cancer. Presence of such procoagulant autoantibodies might predict future complications and should influence treatment strategy.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Accepted: January 18, 1991
Published online: December 11, 2008
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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