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Molecular Mechanisms of Go Signaling

Jiang M. · Bajpayee N.S.

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Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA

Corresponding Author

Dr. Meisheng Jiang

Department of Molecular and Medical Pharmacology

David Geffen School of Medicine, University of California Los Angeles

710 Westwood Plaza, Reed 3127, Los Angeles, CA 90095 (USA)

Tel. +1 310 794 7802, Fax +1 310 794 7380, E-Mail jm@ucla.edu

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Neurosignals 2009;17:23–41

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Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.

© 2009 S. Karger AG, Basel


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Article / Publication Details

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Abstract of Invited Review

Received: March 14, 2008
Accepted: April 09, 2008
Published online: February 12, 2009
Issue release date: February 2009

Number of Print Pages: 19
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

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