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Invited Review

Functions and Regulatory Mechanisms of Gq-Signaling Pathways

Mizuno N. · Itoh H.

Author affiliations

Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan

Corresponding Author

Dr. H. Itoh

Department of Cell Biology, Graduate School of Biological Sciences

Nara Institute of Science and Technology

Takayama, Ikoma, Nara (Japan)

Tel. +81 743 72 5440, Fax +81 743 72 5449, E-Mail hitoh@bs.naist.jp

Related Articles for ""

Neurosignals 2009;17:42–54

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Abstract

Gq family members of heterotrimeric G protein activate β isoforms of phospholipase C that hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate, leading to the protein kinase C activation and intracellular Ca2+ mobilization, respectively. To understand the functions and regulatory mechanisms of Gq-signaling pathways, we first introduce the Gαq-interacting proteins, which function as the effectors and the modulators of Gq. Next, we describe the Pasteurella multocida toxin and YM-254890, which are useful tools to investigate Gq signaling as activator and inhibitor, respectively. Finally, we discuss the physiological function of Gq in developmental brain, especially in neural progenitor cells.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Invited Review

Received: June 14, 2008
Accepted: August 13, 2008
Published online: February 12, 2009
Issue release date: February 2009

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


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