Nephron
Original Paper
Study on Chronic Renal Injuries Induced by Carbon Tetrachloride: Selective Inhibition of the Nephrotoxicity by IrradiationOgawa M.a · Mori T.a · Mori Y.a · Ueda S.a · Azemoto R.a · Makino Y.a · Wakashin Y.a · Ohto M.a · Wakashin M.b · Yoshida H.c · Iesato K.caFirst Department of Internal Medicine and bDepartment of Postgraduate Medical Education Center, Chiba University School of Medicine; cChiba Social Security Hospital, Chiba City, Chiba, Japan
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Article / Publication Details
Accepted: April 15, 1991
Published online: December 11, 2008
Issue release date: 1992
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Carbon tetrachloride (CC14) was intraperitoneally injected into Balb/c mice 4 times at biweekly intervals, and the morphological changes of the liver and kidney were examined during 12 weeks after the last injection. The renal injuries progressed in spite of cessation of CC14 treatment; microcysts with tubular-cell degeneration were manifest on day 42 after the last injection of CC14. At the end of the experiment, however, interstitial fíbrosis with inflammatory cell infiltration was much more prominent. Glomerular changes with IgG deposits also developed following the tubulointerstitial changes. The CC14 treatment induced liver damage as well, but it promptly subsided without formation of cirrhosis. The CC14 nephrotoxicity was completely inhibited by whole body irradiation (200 rad) exposed at each injection of CC14. In contrast, the hepatic damage was not changed by irradiation. These results seem to indicate etiologic independence of renal and hepatic events induced by CC14 treatment. It is also suggested that chronic CC14 nephrotoxicity is mediated, at least in part, by radiosensitive responses of the mice themselves.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Accepted: April 15, 1991
Published online: December 11, 2008
Issue release date: 1992
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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