Nephron

Original Paper

Study on Chronic Renal Injuries Induced by Carbon Tetrachloride: Selective Inhibition of the Nephrotoxicity by Irradiation

Ogawa M.a · Mori T.a · Mori Y.a · Ueda S.a · Azemoto R.a · Makino Y.a · Wakashin Y.a · Ohto M.a · Wakashin M.b · Yoshida H.c · Iesato K.c

Author affiliations

aFirst Department of Internal Medicine and bDepartment of Postgraduate Medical Education Center, Chiba University School of Medicine; cChiba Social Security Hospital, Chiba City, Chiba, Japan

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Nephron 1992;60:68–73

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: April 15, 1991
Published online: December 11, 2008
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Carbon tetrachloride (CC14) was intraperitoneally injected into Balb/c mice 4 times at biweekly intervals, and the morphological changes of the liver and kidney were examined during 12 weeks after the last injection. The renal injuries progressed in spite of cessation of CC14 treatment; microcysts with tubular-cell degeneration were manifest on day 42 after the last injection of CC14. At the end of the experiment, however, interstitial fíbrosis with inflammatory cell infiltration was much more prominent. Glomerular changes with IgG deposits also developed following the tubulointerstitial changes. The CC14 treatment induced liver damage as well, but it promptly subsided without formation of cirrhosis. The CC14 nephrotoxicity was completely inhibited by whole body irradiation (200 rad) exposed at each injection of CC14. In contrast, the hepatic damage was not changed by irradiation. These results seem to indicate etiologic independence of renal and hepatic events induced by CC14 treatment. It is also suggested that chronic CC14 nephrotoxicity is mediated, at least in part, by radiosensitive responses of the mice themselves.

© 1992 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: April 15, 1991
Published online: December 11, 2008
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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