Nephron
Original Paper
Creatol, a Creatinine Metabolite, as a Useful Determinant of Renal FunctionNakamura K.a · Ienaga K.a · Nakano K.b · Nakai M.b · Nakamura Y.b · Hasegawa G.b · Sawada M.b · Kondo M.b · Mori H.c · Kanatsuna T.caDepartment of Natural Products Chemistry, Institute of Bio-Active Science (IBAS), Nippon Zoki Pharmaceutical Co. Ltd., Hyogo; bFirst Department of Internal Medicine, Kyoto Prefectural University of Medicine; cDepartment of Metabolism, Kyoto City Hospital, Kyoto, Japan
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Article / Publication Details
Accepted: March 12, 1993
Published online: December 16, 2008
Issue release date: 1994
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Analysis of creatoi (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated that CTL is a useful determinant of renal function. The existence itself of serum CTL (s-CTL) could be a diagnostic sign for chronic renal failure (CRF): in all normal subjects, s-CTL was undetectable, but s-CTL was detectable in sera of all patients with CRF (s-Cr: > 2.0 mg/dl). And the s-CTL values increased in proportion to the severity of CRF in such patients. Furthermore, the molar ratio (CTL/Cr) in both urine and serum increased significantly in proportion to the severity of CRF. Our results indicated not only hyperproduction of CTL but also higher oxygen stress in patients according to the progression of CRF. The diagnostic importance of the CTL value and the CTL/Cr ratio are discussed.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Accepted: March 12, 1993
Published online: December 16, 2008
Issue release date: 1994
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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