Nephron

Original Paper

Creatol, a Creatinine Metabolite, as a Useful Determinant of Renal Function

Nakamura K.a · Ienaga K.a · Nakano K.b · Nakai M.b · Nakamura Y.b · Hasegawa G.b · Sawada M.b · Kondo M.b · Mori H.c · Kanatsuna T.c

Author affiliations

aDepartment of Natural Products Chemistry, Institute of Bio-Active Science (IBAS), Nippon Zoki Pharmaceutical Co. Ltd., Hyogo; bFirst Department of Internal Medicine, Kyoto Prefectural University of Medicine; cDepartment of Metabolism, Kyoto City Hospital, Kyoto, Japan

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Nephron 1994;66:140–146

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: March 12, 1993
Published online: December 16, 2008
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Analysis of creatoi (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated that CTL is a useful determinant of renal function. The existence itself of serum CTL (s-CTL) could be a diagnostic sign for chronic renal failure (CRF): in all normal subjects, s-CTL was undetectable, but s-CTL was detectable in sera of all patients with CRF (s-Cr: > 2.0 mg/dl). And the s-CTL values increased in proportion to the severity of CRF in such patients. Furthermore, the molar ratio (CTL/Cr) in both urine and serum increased significantly in proportion to the severity of CRF. Our results indicated not only hyperproduction of CTL but also higher oxygen stress in patients according to the progression of CRF. The diagnostic importance of the CTL value and the CTL/Cr ratio are discussed.

© 1994 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: March 12, 1993
Published online: December 16, 2008
Issue release date: 1994

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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