Nephron
Original Paper
Histone-Reactive IgA Antibodies in Adult IgA Nephropathy and Other Primary GlomerulonephritisMonestier M.a · Fasy T.M.b · Novick K.E.a · Losman M.J.a · Rigal D.c · Wong G.Y.d · Terzidis-Trabelsi H.e · Pilatte Y.e · Rostoker G.eaGarden State Cancer Center and Center for Molecular Medicine and Immunology, Newark, N.J., bDepartment of Pathology, Mount Sinai School of Medicine, New York, N.Y., USA; cCentre Régional de Transfusion Sanguine, Lyon, France; dDivision of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA; eService de Néphrologie et INSERM U 139, Hôpital Henri Mondor, Créteil, France
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Article / Publication Details
Accepted: August 27, 1993
Published online: December 17, 2008
Issue release date: 1994
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
The levels of histone-reactive IgA antibodies in the sera of adult patients with IgA mesangial glomerulonephritis, membranous glomerulonephritis, membranoproliferative glomerulonephritis and idiopathic nephrotic syndrome (minimal change disease + segmental glomerulosclerosis + IgM nephropathy) were evaluated by an enzyme-linked immunosorbent assay. Increased levels of IgA antibodies to all five major histones (H1, H2A, H2B, H3, H4) were found in all four disease groups when compared to normal controls. These histone-reactive IgA antibodies were restricted to the IgA1 subclass and their levels did not correlate with the levels of total serum IgA, nor with serum creatinine, creatinine clearance, and 24-hour proteinuria. Increasing ionic strength resulted in only partial inhibition of the binding to histones and, in individual patients, levels of reactivity with individual histones were usually correlated. This study shows that elevated levels of IgA antibodies reactive with self antigens are present in primary glomerulonephritis and extends previous observations indicating that anomalies of the IgA system occur in various forms of primary glomerulonephritis and are not limited to IgA nephropathy.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Accepted: August 27, 1993
Published online: December 17, 2008
Issue release date: 1994
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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