Nephron
Original Paper
Hemorheological and Hemostatic Parameters in Children with Nephrotic Syndrome Undergoing Steroid TherapyAndré E.a · Voisin Ph.b · André J.L.c · Briquel M.E.a · Stoltz J.F.a · Martinet N.a · Alexandre P.aaCentre Régional de Transfusion Sanguine, Vandœuvre-lès-Nancy, bLaboratoire d’Hémorhéologie-Hématologie, Faculté de Médecine, Université de Nancy I, Vandœuvre4ès-Nancy, cUnité de Néphrologie Pédiatrique, Centre Hospitalier Universitaire de Nancy, France
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Article / Publication Details
Accepted: October 05, 1993
Published online: December 17, 2008
Issue release date: 1994
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
Abstract
Disturbances in hemostatic and hemorheological parameters have been investigated in a group of 29 children with nephrotic syndrome: 23 children classified as steroid-sensitive and 6 as steroid-resistant. Studies were performed before prednisone treatment and 3 weeks later, after initiation of steroid therapy. Before treatment, the alterations in hemostatic system involved moderate thrombocytosis with spontaneous aggregation in 19 patients. High levels of fibrinogen, factor VIII, Willebrand factor, protein C, protein S and α2-macroglobulin (α2M) were observed. Factor XII and α1-antitrypsin (α1AT) were lower than normal. Antithrombin III (ATIII) level was normal in the majority of patients. A plasma and blood hyperviscosity syndrome was also observed as well as an increase in erythrocyte aggregation. During treatment, an improvement in the hemostatic parameters was observed in the patients who responded to prednisone. The expected increase in factor VIII (frequently described in the literature) was not observed, while there was a significant increase in protein C. In the steroid-resistant patients, the only significant changes observed were decreased fibrinogen and increased protein C. The hemorheological parameters showed a tendency towards normality regardless of whether or not the treatment provided remission of NS. The relationship between hemorheological and hemostatic factors changes are discussed.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Accepted: October 05, 1993
Published online: December 17, 2008
Issue release date: 1994
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)
For additional information: https://www.karger.com/NEF
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