Nephron

Original Paper

Kidney and Breast Cysts: A Comparative Study of Fluids

Hurley D.K. · Bandy S.M. · Glew R.H. · Morris D.M. · Gardner, Jr. K.D.

Author affiliations

Departments of Physiology, Biochemistry, Surgery, and Medicine, University of New Mexico Health Sciences Center, Albuquerque, N. Mex., USA

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Nephron 1997;77:304–308

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: April 11, 1997
Published online: December 23, 2008
Issue release date: 1997

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

The contributions of amino acids to the overall osmotic activity of cyst fluids were sought in this comparative study of fluids from the cysts of autosomal dominant polycystic disease (ADPKD) and gross cystic disease of the breast (GCDB). Fluids (n = 18) from 18 women with GCDB and from 8 patients with ADPKD (n = 25), grouped on the basis of sodium concentrations, were analyzed for potassium, chloride, protein, and osmolality by routine methods and for amino acids by reversed-phase high-pressure liquid chromatography. Similarities between kidney and breast cyst fluids included relative isosmolality, a wide range of sodium concentrations, an inverse relationship between sodium and potassium concentrations, higher concentrations of amino acids in low-sodium fluids, and significant correlations between sequential concentrations of amino acids in cyst fluids versus blood and some of its components. Therefore, cyst fluids in ADPKD and GCDB share compositional characteristics, and amino acids, possibly of blood protein origin, accumulate in small but osmotically significant amounts in some, particularly low-sodium, cysts of kidney and breast.

© 1997 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: April 11, 1997
Published online: December 23, 2008
Issue release date: 1997

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF


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