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Original Paper

Free Access

A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype

Marfella C.G.A.a · Henninger N.b · LeBlanc S.E.a · Krishnan N.c · Garlick D.S.d · Holzman L.B.e · Imbalzano A.N.a

Author affiliations

Departments of aCell Biology and bNeurology, cRenal Division, Department of Internal Medicine, and dDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, Mass., and eDivision of Nephrology, University of Michigan Medical School, Ann Arbor, Mich., USA

Corresponding Author

Anthony N. Imbalzano

Department of Cell Biology, University of Massachusetts Medical School

55 Lake Avenue North, Worcester, MA 01655 (USA)

Tel. +1 508 856 1029, Fax +1 508 856 5612

E-Mail anthony.imbalzano@umassmed.edu

Related Articles for ""

Kidney Blood Press Res 2008;31:421–432

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Background and Aims: Glomerular diseases are the third leading cause of kidney failure worldwide, behind only diabetes and hypertension. The molecular mechanisms underlying the cause of glomerular diseases are still largely unknown. The identification and characterization of new molecules associated with glomerular function should provide new insights into understanding the diverse group of glomerular diseases. The Chd2 protein belongs to a family of enzymes involved in ATP-dependent chromatin remodeling, suggesting that it likely functions as an epigenetic regulator of gene expression via the modification of chromatin structure. Methods: In this study, we present a detailed histomorphologic characterization of mice containing a mutation in the chromodomain helicase DNA-binding protein 2 (Chd2). Results: We show that Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function. Additionally, serum analysis revealed decreased hemoglobin and hematocrit levels in Chd2-mutant mice, suggesting that the glomerulopathy observed in these mice is associated with anemia. Conclusion: Collectively, the data suggest a role for the Chd2 protein in the maintenance of kidney function.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 30, 2008
Accepted: November 17, 2008
Published online: January 14, 2009
Issue release date: February 2009

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

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