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Morphometric Evaluation of Ultrastructural Changes in Type II Alveolar Cells of Rat Lung Produced by Bromhexine

Gil J. · Thurnheer U.

Author affiliations

Anatomisches Institut der Universität Bern (Direktor: Prof. Dr. E. R. Weibel)

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Respiration 1971;28:438–456

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: December 16, 1970
Accepted: January 18, 1971
Published online: January 09, 2009
Issue release date: 1971

Number of Print Pages: 19
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

The influence exerted by the secretolyticum Bisolvon® on rat lungs was examined. The lungs were fixed for electron microscopy by vascular perfusion of the fixatives in order to preserve the extracellular lining layer of alveoli (surfactant). The appearance of this lining layer was identical in Bisolvon-treated animals as compared with controls. But in Bisolvon-animals peculiar, unusually large forms of lamellated bodies of alveolar cells type II could be observed. A morphometric examination of this material demonstrated that the volume of lamellated bodies within alveolar cells type II, but especially the volume of alveolar epithelial cells type II, as compared with the total volume of lung tissue were clearly increased. The conclusion is drawn that these cells, supposed to represent the major source of alveolar surfactant, proliferate or differentiate under the influence of Bisolvon. The possible significance of this finding for the function of pulmonary surfactant is discussed. Additonally, concentric lamellar bodies, which appear to be proliferations of smooth endoplasmic reticulum, were found in alveolar cells type I.

© 1971 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: December 16, 1970
Accepted: January 18, 1971
Published online: January 09, 2009
Issue release date: 1971

Number of Print Pages: 19
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES


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