Respiration
Pulmonary Arterial Wedge and Left Atrial Pressures and the Site of Hypoxic Pulmonary VasoconstrictionMalik A.B. · Kidd B.S.L.Department of Physiology, Albany Medical College of Union University, Albany, N.Y., and Research Institute, Hospital for Sick Children, University of Toronto, Toronto
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Article / Publication Details
Received: February 03, 1975
Accepted: April 12, 1975
Published online: January 14, 2009
Issue release date: 1976
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
The pulmonary vascular response to breathing 5 % oxygen in nitrogen was studied in anesthetized, artificially ventilated dogs. The pulmonary arterial (Pa), pulmonary arterial wedge (Pw), left atrial (LAP) pressures and pulmonary blood flow (Q) were monitored. The pulmonary arterial catheter was wedged at the mid-lung level. At 10 min of hypoxia, Pa-Pw pressure gradient increased while the Pw-LAP gradient did not change significantly. The Pw and LAP were significantly correlated during room air breating (r = 0.832) and during hypoxia (r = 0.980). The calculated resistance from the pulmonary artery to the wedged catheter (Pa-Pa/Q) increased and the calculated resistance from the wedged catheter (Pa-Pw/Q) did not change significantly. These findings indicate that the mean LAP and Pw pressures are not significantly different during severe hypoxia, and that the increase in pulmonary vascular resistance during hypoxia is due to constriction of the large precapillary vessels.
© 1976 S. Karger AG, Basel
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Article / Publication Details
Received: February 03, 1975
Accepted: April 12, 1975
Published online: January 14, 2009
Issue release date: 1976
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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