Respiration
Immunological Release of Histamine from Human LungII. Studies on Acetylcholine and the Anticholinergic Agent Ipratropium Bromide 1. Medizinische Universitätsklinik Hamburg-Eppendorf (Medical Director: Prof. Dr. H. Bartelheimer), Hamburg, and Abteilung für klinische Immunologie und Allergologie (Director: Prof. Dr.H. G. Thiele), Hamburg
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Article / Publication Details
Received: October 20, 1978
Accepted: January 15, 1979
Published online: January 14, 2009
Issue release date: 1979
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acetylcholine at a concentration of 1 × 10-7M increased the antigen-induced release of histamine by approximately 41%. When the lung tissue was treated with ipratropium bromide before acetylcholine, the competitive inhibition of the cholinergic receptor almost completely abolished this acetylcholine-induced increase of histamine release. Therefore, in our opinion, anticholinergic agents are primarily useful in vagus-controlled chronic obstructive ventilatory disorders; they are of secondary importance in allergic bronchial asthma.
© 1979 S. Karger AG, Basel
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Article / Publication Details
Received: October 20, 1978
Accepted: January 15, 1979
Published online: January 14, 2009
Issue release date: 1979
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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