Respiration

 

Effect of Intravenous Histamine, Allergen (Ascaris suum Extract) and Compound 48/80 and Inhaled Allergen-Aerosol on Bronchoconstriction and Histamine Release

Zimmermann I. · Ulmer W.T.

Author affiliations

Medizinische Universitätsklinik und Poliklinik (Chefarzt: Prof. Dr. W.T. Ulmer), Berufsgenossenschaftliche Krankenanstalten ‘Bergmannsheil Bochum’

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Respiration 1981;42:30–42

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: September 22, 1980
Accepted: January 10, 1981
Published online: November 11, 2010
Issue release date: 1981

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

The effect of a histamine releaser (48/80), an antigen (Ascaris suum extract) and of exogenous histamine infusion on antigen aerosol-induced bronchoconstriction was investigated in 24 mongrel dogs. During these substance infusions, the high values of arterial plasma histamine did not correlate with the degree of bronchoconstriction. Further, a severe bronchoconstriction with a relatively low arterial plasma histamine concentration was observed during antigen inhalation. During substance inhalation, a high local concentration of histamine is assumed to explain the increased bronchial ‘sensitivity’ to actual plasma levels of histamine. Also, the responsiveness of the bronchial tree to antigen aerosol was observed to be reduced 90 min after induction of a strong histamine release. The importance of histamine in the first phase of immediate hypersensitivity is discussed.

© 1981 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: September 22, 1980
Accepted: January 10, 1981
Published online: November 11, 2010
Issue release date: 1981

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES


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