Respiration
Original Paper
Effect of Dietary Caffeine on Airway Reactivity in AsthmaCrivelli M. · Wahlländer A. · Jost G. · Preisig R. · Bachofen H.Department of Medicine and Institute of Clinical Pharmacology, University of Berne, Switzerland
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Article / Publication Details
Received: June 24, 1985
Accepted: April 20, 1986
Published online: January 16, 2009
Issue release date: 1986
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
The potential influence of dietary caffeine on bronchoprovocation challenges with carbachol was examined in 7 patients with asymptomatic asthma. In a double-blind fashion placebo or caffeine (6 mg/kg body weight; equivalent to approximately 4 cups of coffee) solved in orange juice was administered, and carbachol challenges were performed. The average peak serum concentration achieved 60 min after dosing was 7.6 ± SD 2.1 mg/l. These caffeine levels did not produce any appreciable attenuation of the bronchoconstrictor response to carbachol inhalations. It thus appears that dietary caffeine is barely a cause of erroneous interpretations of bronchoprovocation challenges with carbachol.
© 1986 S. Karger AG, Basel
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Article / Publication Details
Received: June 24, 1985
Accepted: April 20, 1986
Published online: January 16, 2009
Issue release date: 1986
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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