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Clinical Efficacy of Ambroxol in the Treatment of Bronchial Stasis. Clinical Trial in 120 Patients at Two Different Doses

Clinical Trial in 120 Patients at Two Different Doses

Germouty J.a · Jirou-Najou J.L.b

Author affiliations

aFaculté de Médecine, Limoges, and bDépartement de Médecine, Laboratoires Boehringer-Ingelheim, Reims, France

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Respiration 1987;51:37–41

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 16, 2009
Issue release date: 1987

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

Mucosolvan is a ‘mucus-modifier’ whose active compound is ambroxol. The aim of our research was to determine its clinical efficacy in the treatment of bronchial stasis by carrying out two successive double-blind studies in two parallel groups of patients and comparing ambroxol with placebo in a treatment lasting 10 days. The first trial involving 60 patients daily treated with 120 mg of ambroxol showed significant differences (p < 0.05) in sputum volume, sputum viscosity, difficulty of expectoration, and severity of cough when compared with the placebo group. The two groups of patients were initially well matched and the drug was well tolerated. In a second trial involving 60 new patients daily treated with 30 mg of ambroxol, the drug showed no clear clinical effects. We conclude that ambroxol is an effective ‘mucus modifier’ and is well tolerated at a dose of 120 mg/day.

© 1987 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: January 16, 2009
Issue release date: 1987

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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