Respiration
Original Paper
Lung Function Disturbances versus Respiratory Muscle Fatigue in Patients with Systemic Lupus erythematosusWorth H.a · Grahn S.a · Lakomek H.J.b · Bremer G.b · Goeckenjan G.aaDepartment of Cardiology, Pneumology and Angiology and bDepartment of Endocrinology and Rheumatology, MNR Clinic, University of Düsseldorf, FRG
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Article / Publication Details
Received: April 10, 1987
Accepted: October 07, 1987
Published online: January 16, 2009
Issue release date: 1988
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
In 23 consecutive patients (mean age, 38.6 years) with systemic lupus erythematosus (SLE) and in 17 healthy subjects (mean age, 37.5 years) fatigue of respiratory (diaphragm, musculi intercostales externi) and leg muscles (musculus gastrocnemius) was determined comparatively by electromyography. Additionally, routine lung function parameters, including maximum inspiratory (PImax) and expiratory (PEmax) mouth pressures, were measured. The SLE patients showed lower values of vital capacity (VC), total lung capacity (TLC), thoracic gas volume (TGV), FEV1, PImax and PEmax than the healthy controls, while FEV1/VC, residual volume and specific airway conductance were not significantly different in either group. Lung compliance, corrected for TGV, was normal in the SLE group. Breathing through stenoses with increasing resistances resulted in fatigue of the diaphragm in 73 % of the SLE group and in 41 % of the control group. The corresponding values of the external intercostal muscles were 74% (SLE group) and 29% (control group). Electromyographic signs of respiratory and leg muscle fatigue occurred at lower loads in the SLE group than in the healthy subjects. The pattern of lung function data in patients with SLE was characteristic neither of lung restriction nor of airway obstruction. Respiratory muscle weakness can explain the decrease in TLC, VC, TGV, FEV1 PImax and PEmaχ
© 1988 S. Karger AG, Basel
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Article / Publication Details
Received: April 10, 1987
Accepted: October 07, 1987
Published online: January 16, 2009
Issue release date: 1988
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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