Respiration
Original Paper
Effects of Single Doses of Propiomazine, a Phenothiazine Hypnotic, on Sleep and Oxygenation in Patients with Stable Chronic Obstructive Pulmonary DiseaseMidgren B.a · Hansson L.a · Ahlmann S.b · Elmqvist D.bDepartments of aLung Medicine and bClinical Neurophysiology, University Hospital, Lund, Sweden
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Article / Publication Details
Received: October 31, 1989
Accepted: May 09, 1990
Published online: January 20, 2009
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
Serious respiratory depression may occur in patients with chronic obstructive pulmonary disease (COPD), receiving hypnotics during acute exacerbations. However, in a previous study on oxygenation during sleep in patients with stable hypoxemic non-hypercapnic COPD, we were unable to demonstrate a significant negative effect from single doses of nitrazepam and flunitrazepam. We have now investigated the effects of propiomazine, a phenothiazine hypnotic, in a double-blind randomized cross-over study of oxygen saturation and apneas during sleep and other sleep variables in 12 non-obese hypoxemic but clinically stable theophylline-treated COPD patients (PaO2 8.1 kPa, PaCO2 5.6 kPa, FEV1 31% of predicted value). None of the respiratory variables were adversely affected by a single oral dose of 25 mg propiomazine, whereas total sleeping time and the sleep efficiency index increased
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: October 31, 1989
Accepted: May 09, 1990
Published online: January 20, 2009
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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