Respiration

Original Paper

Role of Bromhexine in Exacerbations of Bronchiectasis

Double-Blind Randomized Multicenter Study versus Placebo

Olivieri D.a · Ciaccia A.b · Marangio E.a · Marsico S.c · Todisco T.d · Del Vita M.e

Author affiliations

aDepartment of Respiratory Diseases, University of Parma, Italy; bDepartment of Phthisiology and Respiratory Diseases, University of Ferrara, Italy; cDepartment of Phthisiology and Respiratory Diseases, University of Catanzaro, Italy; dDepartment of Respiratory Pathophysiology, University of Perugia, Italy, and eMedical Department, Boehringer Ingelheim Italia, Florence, Italy

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Respiration 1991;58:117–121

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 26, 1989
Accepted: June 05, 1991
Published online: January 20, 2009
Issue release date: 1991

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES

Abstract

The effectiveness of bromhexine in the treatment of patients with bronchiectasis, in a stage of clinical exacerbation, was assessed in a double-blind, placebo-controlled trial involving 88 in-patients. Bronchiectasis was diagnosed by bronchography and/or CT scan. Bromhexine or matched placebo was administered as 30-mg capsules three times daily per os. Ceftazidine, 1 g i.m., was given to all patients once a day for the first week only. Bromhexine seemed to improve the clinical picture, with significantly positive trends for expectoration, quantity of sputum and auscultatory findings. It also increased the FEV1 and was well-tolerated. Both patients and investigators judged it efficacious

© 1991 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 26, 1989
Accepted: June 05, 1991
Published online: January 20, 2009
Issue release date: 1991

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: https://www.karger.com/RES


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