Respiration
Original Paper
Influences of the Cellular and Humoral Immune System in Bronchoalveolar Lavage on Lung Function in Pulmonary SarcoidosisPopp W.a · Herkner K.b · Böck A.b · Rauscher H.a · Wanke T.a · Ritschka L.a · Zwick H.aaPulmonary Department, KH der Stadt Wien-Lainz, and bClinic of Pediatrics, University of Vienna, Austria
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Article / Publication Details
Received: May 29, 1991
Accepted: December 04, 1991
Published online: January 20, 2009
Issue release date: 1992
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
Abstract
We investigated the changes in the cellular and humoral immune system in bronchoalveolar lavage (BAL) performed in 22 patients with pulmonary sarcoidosis and in 14 normal control subjects and their interactions with lung function parameters. Lymphocytosis, the increase in OKT4+ lymphocytes and OKT4+OKDR+ lymphocytes correlated with the increase in immunoglobulins, especially IgG, IgA and kappa chain assembled immunoglobulins. The transferrin levels obtained in BAL were found to be higher in patients with sarcoidosis, and they correlated with the cellular and, more closely, with other humoral findings. A negative correlation existed between the ventilatory parameters and the cell count and humoral findings. In addition, we found a negative correlation between the diffusing capacity for carbon monoxide and other cellular findings, which was most pronounced with reference to lymphocytes, OKT4+ lymphocytes and the OKT4+/OKT8+ ratio. These results underscore the role of OKT4+ lymphocytes, activated OKT4+OKDR+ lymphocytes and transferrin in the increase in immunoglobulins, mainly kappa chain isotypes. Because of the relationship between these changes and ventilatory parameters, and the diffusing capacity, the above results also reveal the clinical relevance of our findings.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: May 29, 1991
Accepted: December 04, 1991
Published online: January 20, 2009
Issue release date: 1992
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: https://www.karger.com/RES
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