Digestion
Original Paper
Fat Necrosis – a Cause of Pancreatic Parenchymal Necrosis?Schmidt H. · Lankisch P.G.Medizinische Universitätsklinik, Göttingen, and Medizinische Klinik II, Wiesbaden
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Article / Publication Details
Received: September 20, 1976
Accepted: January 01, 1977
Published online: January 27, 2009
Issue release date: 1978
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Abstract
Acute pancreatic necrosis resulted when oleic acid or olive oil was injected into the pancreatic duct of rats. After injection of droplets of both lipids into the pancreatic interstitial tissue, coagulation-type necrosis of acinar tissue developed adjacent to these droplets. Mono-olein or paraffin oil caused no histological alterations of acinar cells. It is concluded that (1) the deleterious effect of olive oil on the pancreas is mediated through fatty acids released by pancreatic lipase, and (2) fatty acids split off in fat necrosis of acute pancreatitis may damage adjacent pancreatic acinar tissue.
© 1978 S. Karger AG, Basel
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Article / Publication Details
Received: September 20, 1976
Accepted: January 01, 1977
Published online: January 27, 2009
Issue release date: 1978
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
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