Digestion
Original Paper
Treatment of Active Duodenal Ulcer with Oral Cimetidine: a Multicenter Controlled Endoscopic TrialPorro G.B. · Cheli R. · Dobrilla G. · Verme G. · Molinari F. · Pera A. · Petrillo M. · Valentini M.Ospedale ‘L. Sacco’, Servizio di Gastroenterologia, Milan; Ospedale San Martino, Divisione di Gastroenterologia, Genoa; Ospedale Regionale, Divisione di Gastroenterologia, Bolzano, and Ospedale Mauriziano, Divisione di Gastroenterologia, Torino
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Article / Publication Details
Received: June 01, 1977
Accepted: December 28, 1977
Published online: January 27, 2009
Issue release date: 1978
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Abstract
A double-blind 4-week trial of cimetidine (1 g daily) versus placebo was conducted in 68 adult outpatients with active duodenal ulceration endoscopically confirmed. 3 of the patients admitted to the study (1 on cimetidine and 2 on placebo) did not complete the trial. After 4 weeks of treatment, 25 of 33 patients (76%) receiving cimetidine had healed their ulcers compared with 15 (47%) of 32 patients receiving placebo (p < 0.02). Antacid consumption was also significantly decreased by cimetidine when compared with placebo. Tolerability of the drug was good.
© 1978 S. Karger AG, Basel
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Article / Publication Details
Received: June 01, 1977
Accepted: December 28, 1977
Published online: January 27, 2009
Issue release date: 1978
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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