Digestion
Original Paper
Effects of Pancreatic Duct Ligation on the Hamster Intestinal MucosaHistological Findings Groupe de Recherche de Biologie et Pathologie digestive, Inserm U 151, CHU Rangueil, Toulouse
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Article / Publication Details
Received: January 05, 1979
Published online: January 27, 2009
Issue release date: 1980
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Abstract
After pancreatic duct ligation good correlations were observed between degenerative signs of the exocrine pancreas and ultrastructural changes of intestinal epithelial cells: hypertrophy of Paneth and goblet cells; hyperplasia of Paneth cells, mucous cells and ‘intermediate granular cells’ after the 10th day. On the 7th day, the absorbing area of the intestine (villi area and microvilli area) decrease significantly. These cytological changes partially disappear after the 15th day concomitant to a partial regeneration of the exocrine pancreas. These findings suggest correlations between the epithelial cells of the small intestine and exocrine pancreatic secretion. Different possibilities (direct action of the pancreatic juice or indirect mechanisms) are discussed and proposed to explain the morphological variations of the intestinal mucosa after pancreatic duct ligation.
© 1980 S. Karger AG, Basel
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Article / Publication Details
Received: January 05, 1979
Published online: January 27, 2009
Issue release date: 1980
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
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