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Original Paper

Discontinuation of Immunosuppressive Therapy in Hepatitis B Surface Antigen-Positive Chronic Hepatitis: Effect on Viral Replication and on Liver Cell Damage

Hess G. · Manns M. · Hütteroth T.H. · Meyer zum Büschenfelde K.-H.

Author affiliations

I. Medizinische Klinik der Johannes Gutenberg-Universität Mainz, FRG

Related Articles for ""

Digestion 1987;36:47–54

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 1985
Published online: January 29, 2009
Issue release date: 1987

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Immunosuppressive therapy was stopped in 12 individuals positive for hepatitis Be antigen (HBeAg) and hepatitis B surface antigen (HBsAg) and in 4 individuals positive for HBsAg but negative for HBeAg. Discontinuation of immunosuppressive therapy in HBeAg-positive patients was always associated with a bout of hepatitis and elimination of HBeAg in 8/12 patients. One patient died from liver failure and 2 patients experienced a decompensation of their liver disease indicating that this approach might be harmful if used therapeutically. A bout of hepatitis was not noted in any of the individuals negative for HBeAg when the immunsuppressive therapy was stopped, implying that this event is not potentially harmful to the patient.

© 1987 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 1985
Published online: January 29, 2009
Issue release date: 1987

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


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