Digestion

Original Paper

Effect of Metoclopramide on Transmural Oesophageal Variceal Pressure and Portal Blood Flow in Cirrhotic Patients

Taranto D. · Suozzo R. · de Sio I. · Romano M. · Caporaso N. · Del Vecchio Blanco C. · Coltorti M.

Author affiliations

Istituto di Medicina Generale e Metodologia Clinica, First School of Medicine, University of Naples, Italy

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Digestion 1990;47:56–60

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 27, 1990
Published online: February 03, 2009
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7% decrease, p < 0.05 vs. basal value). In order to evaluate if the metoclopramide-induced drop in transmural variceal pressure was due to an effect on portal haemodynamics, we also measured, by means of real time and pulsed Doppler ultrasonography, portal vein diameter, mean velocity of portal flow, and portal venous flow. No significant change was observed before and after metoclopramide. In conclusion, metoclopramide, which increases lower oesophageal sphincter pressure, significantly decreases transmural variceal pressure in cirrhotic patients. However, it does not have any effect on portal haemodynamics.

© 1990 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 27, 1990
Published online: February 03, 2009
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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