Digestion
Original Paper
Fat and Gastric Acid SecretionPetersen F.a · Olsen O.b · Vedel Jepsen L.a · Christiansen J.aaDepartment of Surgery D, Glostrup Hospital, and bDepartment of, Surgery C, Rigshospitalet, University of Copenhagen, Denmark
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Article / Publication Details
Received: November 29, 1991
Published online: February 04, 2009
Issue release date: 1992
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Abstract
To evaluate the importance of the terminal carboxyl group of the oleic acid molecule in the inhibition of gastric acid secretion, 6 normal persons were stimulated twice with duodenal perfusates containing either 20 mM oleic acid or 20 mM oleyl alcohol. Oleic acid significantly inhibited the gastric acid secretion stimulated by pentagastrin (100 ng/kg/h) and increased the levels of secretin in plasma. The effect of oleyl alcohol was insignificant. It is concluded that the carboxyl group of the fat molecule has an important role in the inhibition of gastric acid secretion, and the effect could in part be attributable to the release of secretin into plasma.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: November 29, 1991
Published online: February 04, 2009
Issue release date: 1992
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
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