Digestion
Systemic Factors in Esophageal Mucosal ProtectionTobey N.A.Tulane University Medical Center, New Orleans, La., USA
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Article / Publication Details
Published online: February 05, 2009
Issue release date: 1995
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Abstract
Blood bicarbonate is an important systemic factor in esophageal protection due to its capacity for buffering H+ either in the lumen, at the epithelial surface, within the intercellular space, or within the cell. The ability to buffer within the lumen is in part dependent on submucosal gland secretion, while buffering in the intercellular space depends on bicarbonate diffusion from blood, and intracellular protection depends on the presence of basolateral membrane bicarbonate transport via a mechanism such as the Na+-dependent CI-/HCO3 exchanger.
© 1995 S. Karger AG, Basel
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Article / Publication Details
Published online: February 05, 2009
Issue release date: 1995
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)
For additional information: https://www.karger.com/DIG
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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