Acta Haematologica
Case Report
Chronic Neutrophilic Leukemia Evolving from a Myelodysplastic SyndromePascucci M.a · Dorion P.a · Makary A.b · Froberg M.K.caDepartment of Laboratory Medicine, and bDepartment of Hematology, Geisinger Medical Center, Danville, Pa., and cDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minn., USA
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Article / Publication Details
Received: April 11, 1996
Accepted: January 13, 1997
Published online: February 17, 2009
Issue release date: 1997
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Abstract
Chronic neutrophilic leukemia (CNL) is a rare hematologic disorder usually presenting with a persistent neutrophilia in the leukemoid range (WBC > 40-50 × 109/1) and consisting largely of mature neutrophils. Patients have no obvious cause for an elevated white count and typically have an elevated leukocyte alkaline phosphatase score, hepatosplenomegaly, elevated vitamin B12 and are Philadelphia chromosome-negative. CNL has occasionally been associated with paraproteinemia or outright myeloma. Dysplastic features within the neutrophils in CNL have rarely been reported. We report the clinical, pathological and cytogenetic features of a case of CNL in an elderly white female initially diagosed with refractory anemia with excess blasts, which subsequently progressed to CNL.
© 1997 S. Karger AG, Basel
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Article / Publication Details
Received: April 11, 1996
Accepted: January 13, 1997
Published online: February 17, 2009
Issue release date: 1997
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
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