Acta Haematologica
Original Paper
Effect of Verapamil on Platelet Surface Ultrastructure and Calcium ContentDjaldetti M. · Gilgal R. · Fishman P. · Zahavi I.Departments of Medicine ‘B’ and ‘C, Laboratory of Hematology Research and Electron Microscopy Unit, Hasharon Hospital, Tel Aviv University Medical School, Petah-Tiqva, Israel
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Article / Publication Details
Received: February 18, 1987
Accepted: June 02, 1987
Published online: February 24, 2009
Issue release date: 1988
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Abstract
The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.
© 1988 S. Karger AG, Basel
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Article / Publication Details
Received: February 18, 1987
Accepted: June 02, 1987
Published online: February 24, 2009
Issue release date: 1988
Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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