Acta Haematologica
Original Paper
Congenital Dyserythropoietic Anaemia (Type II) Presenting with HaemosiderosisBird A.R.a · Jacobs P.a · Moores P.baUniversity of Cape Town Leukaemia Centre and Department of Haematology, Groote Schuur Hospital, Observatory, Cape, and bNatal Blood Transfusion Service, Pinetown, Natal, South Africa
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Article / Publication Details
Received: January 27, 1987
Accepted: April 14, 1987
Published online: February 25, 2009
Issue release date: 1987
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
Abstract
A 39-year-old female with type II congenital dyserythropoiesis presented with iron overload. The clinical and haematologic features were an anaemia of variable severity, splenomegaly, numerous bizarre and binucleate normoblasts in the bone marrow, with prominent submembranous cisternae in the late forms, a positive Ham’s acid lysis test and aberrant expression of the I and i red cell antigens. The iron overload resulted from gross ineffective erythropoiesis, with accelerated plasma iron turnover and increased absorption aggravated by inappropriate replacement therapy for past episodes of anaemia
© 1987 S. Karger AG, Basel
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Article / Publication Details
Received: January 27, 1987
Accepted: April 14, 1987
Published online: February 25, 2009
Issue release date: 1987
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)
For additional information: https://www.karger.com/AHA
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