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Clinical Study

Phase II Study of Docetaxel and Gefitinib as Second-Line Therapy in Gemcitabine Pretreated Patients with Advanced Pancreatic Cancer

Brell J.M.a · Matin K.b · Evans T.b · Volkin R.L.b · Kiefer G.J.b · Schlesselman J.J.b · Dranko S.b · Rath L.a · Schmotzer A.b · Lenzner D.b · Ramanathan R.K.b

Author affiliations

aUniversity Hospitals Case Medical Center, Ireland Cancer Center, Cleveland, Ohio, and bUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pa., USA

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Oncology 2009;76:270–274

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: June 25, 2008
Accepted: September 11, 2008
Published online: March 04, 2009
Issue release date: March 2009

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Background: There is no standard second-line therapy for advanced pancreatic cancer (APC). We evaluated the epidermal growth factor receptor (EGFR) inhibitor gefitinib and docetaxel in a phase II study following gemcitabine failure. Methods: EGFR overexpression was not required. The initial docetaxel dose was 75 mg/m2 on day 1 every 21 days. Due to febrile neutropenia in 8 of the first 18 patients, the dose was reduced to 60 mg/m2. Gefitinib, 250 mg/day orally, was given continuously. Results: Forty-one patients received treatment and were evaluable. Febrile neutropenia was seen in 11 patients (27%), with most events occurring at the docetaxel dose of 75 mg/m2 (8 of 18 patients). Common treatment-related grade 3/4 toxicities were: fatigue (7%), nausea (7%), diarrhea (5%) and vomiting (2%). There was 1 partial response and stable disease in 19 patients. Time to progression was 1.8 months and median survival was 4.5 months (95% CI 2.9–5.7). Conclusion: The tolerability and feasibility of second-line therapy for APC was demonstrated. The combination of gefitinib and docetaxel showed evidence of limited efficacy.

© 2009 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: June 25, 2008
Accepted: September 11, 2008
Published online: March 04, 2009
Issue release date: March 2009

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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